Journal of Applied Oral Science · Published 2026-01-01 · DOI 10.1590/1678-7765-2026-0091
Abstract Hyaluronic acid (HA) is important for tissue repair, especially in oral soft tissue healing. Objective: This study aimed to evaluate the effect of HA on gingival healing and its relationship with heat shock protein 47 (HSP 47), which binds to procollagen. Methodology: 40 female Wistar albino rats were divided into two groups: a control (Group C) and an HA-treated group (Group H), each split into four subgroups for different time points (t1, t3, t7, t14 days). Excisional wounds were made in the palates of all rats. Group H received topical HA gel, whereas Group C received no treatment. HSP 47 levels were measured using enzyme-linked immunosorbent assay, and wound areas were analyzed with ImageJ. Results: No significant difference in HSP 47 levels was observed between groups (p>0.05). However, wound areas in Group C were significantly larger than in Group H on day 3 (p=0.009). HSP 47 levels increased in both groups, with higher values on day 1 (p=0.043). Wound areas decreased over time in both groups, with significant reduction in Group H from days 1 to 3 (p=0.043). Conclusion: Topical HA gel may accelerate early periodontal wound healing but failed to significantly affect HSP 47 levels.
Abstract from DOAJ. Public domain (CC0 1.0).
Read the article at the publisher →