Pediatric Hematology Oncology Journal · Published 2026-01-12 · DOI 10.1016/j.phoj.2025.100800
Somatic malignant transformation (SMT) is defined as the development of non germ cell malignant neoplasm within a teratoma. Malignant change can occur in any of the various components of the three germ cell layers. In adults, more than 80 % of all malignant transformations are squamous cell carcinoma, the rest being adenocarcinoma and carcinoid tumor. In children, SMT are very uncommon and reports are limited.We report a case series of three children who presented with SMT of a teratoma. We also undertook a literature search of published reports on SMT in children.
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