Acta Medica Bulgarica · Published 2026-06-01 · DOI 10.2478/amb-2026-0056
G. Kotov, P. Ermencheva, R. Shumnalieva, G. P. Georgiev, A. Zaralieva, S. Monov
Knee osteoarthritis (KOA) is a common joint disorder affecting the elderly population. Conservative treatment includes lifestyle modifications, weight loss, physiotherapy, nonsteroidal anti-inflammatory drugs, chondroprotective agents, intra-articular application of steroids, hyaluronic acid, and autologous blood component injections. Obesity-related KOA has recently been extensively studied as a separate disease, and there are currently no explicit guidelines regarding its treatment. Currently, there is only a few literature data on the intra-articular administration of autologous conditioned serum (ACS) in subjects with KOA, which suggests an improvement in pain management and functional impairment. However, no separate studies have been performed for obesity-related KOA. Therefore, the aim of our study was to evaluate the efficacy and safety of ACS in the treatment of obesity-related KOA.
Abstract from DOAJ. Public domain (CC0 1.0).
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Kotov, G., Ermencheva, P., Shumnalieva, R., et al. (2026). Autologous Conditioned Serum in the Therapy of Obesity-Related Knee Osteoarthritis. Acta Medica Bulgarica. https://doi.org/10.2478/amb-2026-0056