BMJ Neurology Open · Published 2026-07-01 · DOI 10.1136/bmjno-2026-001692
João Pedro Lima, Lawrence Mbuagbaw, Manya Prasad, Amit Kumar, Guy Sadeu Wafeu, Romain Bonnet, Thomas Agoritsas, Sheyu Li, Zhanming Liu, Pablo Alonso-Coello, Fábio Akio Nishijuka, Reza Mirza, Caroline Matos Silva, Rajaa Alshanketi, Imtinan Khalid Alsahafi, Alanood Alnuaimi, Anja Fog Heen, Peter Mattingly, Sheri A Keitz, Agustin Bengolea, Ariel Izcovich, Surbhi Gupta, Priyanka Aggarwal, Jessyca Matos Silva, Lisa Schwartz, Derek K. Chu, Gordon Guyatt
Objectives In patients living with advanced dementia, the intensity of care during life-threatening infections remains controversial and marked by wide variation in practice. This international survey investigated physicians’ and physicians-in-training’s management choices for individuals with advanced dementia and the factors associated with those choices.Design Vignette-based survey.Setting Twelve countries across five continents.Methods We administered our vignette-based survey to medical students, residents and physicians. The survey elicited participants’ views on whether antibiotics should be administered to an elderly patient with advanced dementia and very poor quality of life, presenting with bacterial pneumonia. We explored factors associated with treatment choices using univariable analysis and multiple logistic regression models.Results Of the 785 participants (age, mean (SD): 31.1 (11.5) years), one-third (31.2%) resided in the Region of the Americas, 21.9% in Europe, 16.2% in the Eastern Mediterranean region and 17.1% in China. In the univariable analysis, choice to treat was associated with younger age, country/WHO region (African region highest overall, European region lowest overall), stage of medical training (medical student most inclined to treat) and absence of medical assistance in dying (MAiD) legislation. Multivariable analyses provided evidence that country was the variable most strongly associated with the choice to treat with antibiotics (Cameroon, China, Saudi Arabia highest; Norway, Switzerland, Spain lowest), with the presence of MAiD legislation also strongly associated (OR 0.35, 95% CI 0.23 to 0.51). Age (OR 0.82, 95% CI 0.66 to 1.00) and religiosity level (OR 0.93, 95% CI 0.87 to 0.99) showed weaker associations with treatment decisions.Conclusion Inclination to treat individuals with advanced dementia who develop pneumonia varies greatly between and within jurisdictions. Social factors (in particular country but also presence of MAiD legislation) proved the most prominent associations, with individual characteristics much less influential. These findings underscore the importance of contextual and cultural factors in value-sensitive clinical decisions.Registration We registered the protocol at Open Science Framework (osf.io/6kfbt).
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Lima, J., Mbuagbaw, L., Prasad, M., et al. (2026). Clinicians’ decisions about antibiotic treatment in advanced dementia: an international survey. BMJ Neurology Open. https://doi.org/10.1136/bmjno-2026-001692