Clinical Practice and Cases in Emergency Medicine · Published 2026-04-15 · DOI 10.5811/cpcem.53141
Case Presentation: We present the case of a 53-year-old female with darting eye movements and difficulty walking who was found to have opsoclonus-myoclonus syndrome only after multiple presentations to emergency departments over five days. Discussion: Adult-onset opsoclonus-myoclonus syndrome is a rare central nervous system disease typically associated with paraneoplastic or idiopathic etiologies. With non-specific symptom presentation, this condition is commonly misdiagnosed in adults, leading to diagnostic delays and long-term motor and cognitive sequelae.
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