Infectious Diseases and Therapy · Published 2026-06-24 · DOI 10.1007/s40121-026-01381-w
Christoph Boesecke, Kimberly Workowski, Stuart C. Gordon, Barbra Cave, John Marcinak, Michael G. Miller, Dimitri Semizarov, Anne Welhaven, Axel Baumgarten
Abstract Introduction In a phase 3b study, glecaprevir/pibrentasvir (G/P) for 8 weeks was well tolerated and effective in treatment-naive adults with acute hepatitis C virus (HCV) infection. Here we analyze the efficacy and safety of G/P in adults with acute HCV infection with a history of prior HCV infection. Methods Participants with acute HCV were stratified by presence of prior HCV infection. Efficacy was assessed in the intention-to-treat population (ITT; all patients receiving ≥ 1 G/P dose) and modified ITT virologic failure population, which excluded non-virologic failures (mITT-VF). Safety (adverse events [AEs] and laboratory values) was assessed, as well as viral kinetics. Results Among 286 participants, 52 (18.2%) had ≥ 1 prior HCV infection and 234 (81.8%) did not. High-risk characteristics in those with prior infection versus those without: human immunodeficiency virus (HIV) coinfection, 92.3% versus 40.2%; unprotected male–male sexual activity, 78.8% versus 63.7%; and current/recent injection drug use, 23.1% versus 12.4%, respectively. In the ITT, SVR12 was 98.1% (95% confidence interval [CI] 89.9–99.7) in those with a prior infection and 95.7% (95% CI 92.3–97.7) in those without. There were no virologic failures (SVR12 = 100% in the mITT-VF). Rates of serious AEs (5.8% versus 3.0%) and treatment-related AEs (17.3% versus 15.4%) were similar in those with or without prior HCV infection. Conclusions Individuals with acute HCV infection with a history of prior HCV infection can be successfully treated with G/P. Risk of reinfection in high-risk populations, such as high-risk sexual activity or injection drug use, highlights the need for ongoing testing for reinfection along with subsequent treatment. Trial Registration ClinicalTrials.gov identifier: NCT04903626.
Abstract from DOAJ. Public domain (CC0 1.0).
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Boesecke, C., Workowski, K., Gordon, S., et al. (2026). Glecaprevir/Pibrentasvir for Acute Hepatitis C Virus Infection in Individuals with a History of Prior Hepatitis C Infection. Infectious Diseases and Therapy. https://doi.org/10.1007/s40121-026-01381-w