Association between age at first cannabis use, anxiety and depressive symptoms, and cannabis dependence by sex among U.S. young adults

Psychiatry Research Communications · Published 2025-09-17 · DOI 10.1016/j.psycom.2025.100228

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Abstract

Background: This study investigates whether the association between age at first cannabis use, anxiety and depressive symptoms (modeled alone and together), and cannabis dependence varies by sex. Method: Cross-sectional online study with 451 U.S. young adults in 2021 who used cannabis in the past 30 days. Results: In the model with both anxiety and depression, cannabis dependence was associated with anxiety symptoms only in males (p = .0001) and depressive symptoms only in females (p = .007). Conclusion: Modeling anxiety and depression co-occurrence provided unique insight into sex-specific associations between mental health symptoms and cannabis dependence.

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Publication details

Year
2025

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