Otolaryngology Case Reports · Published 2026-03-07 · DOI 10.1016/j.xocr.2026.100740
Background: Metastatic involvement of the thyroid gland is uncommon, and metastasis from gynecologic malignancies is exceedingly rare. To our knowledge, thyroid metastasis originating from primary fallopian tube carcinoma has not previously been reported. Case presentation: A 75-year-old woman underwent surgery for high-grade serous carcinoma of the left fallopian tube 5 years earlier. Seventeen months postoperatively, recurrence in the para-aortic lymph nodes was detected. She subsequently received systemic chemotherapy with paclitaxel, carboplatin, and bevacizumab, followed by niraparib for approximately 19 months. Treatment was discontinued due to recurrent adverse events, including bone marrow suppression, and best supportive care (BSC) was initiated. Approximately 2 years after transitioning to BSC, she developed progressive anterior neck swelling. Imaging revealed enlargement of the para-aortic and bilateral common iliac lymph nodes, along with newly identified cervical lymphadenopathy and diffuse enlargement of the thyroid gland. Fine-needle aspiration cytology demonstrated malignant cells lacking nuclear features of papillary thyroid carcinoma. Core-needle biopsy confirmed adenocarcinoma histologically concordant with the previously resected fallopian tube carcinoma. Immunohistochemistry revealed positivity for Wilms tumor 1 and estrogen receptor and negativity for thyroglobulin and thyroid transcription factor-1, confirming metastatic Müllerian carcinoma. Palliative management included opioid analgesics for abdominal pain and compression therapy for lower limb lymphedema. The patient remained clinically stable for 14 months following diagnosis. Conclusion: Thyroid metastasis from fallopian tube carcinoma can occur years after initial treatment. In patients with a history of gynecologic malignancy presenting with neck swelling, metastatic disease should be considered. Histopathological confirmation with immunohistochemistry is critical for accurate diagnosis.
Abstract from DOAJ. Public domain (CC0 1.0).
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