BioMedInformatics · Published 2026-06-15 · DOI 10.3390/biomedinformatics6030036
Noor S. Jozi, Ghaida A. Al-Suhail, Viet-Thanh Pham
Lung cancer is the deadliest cause of cancer-related deaths worldwide, and early and accurate detection is key to improving patient outcomes. IQ-OTH/NCCD CT scan images are used in this study to present an optimized computer-aided diagnosis (CAD) framework for lung cancer detection. In order to extract deep features and improve diagnostic accuracy, a weighted geometric mean (WGM) ensemble of pretrained convolutional neural networks (CNNs) called the LCD-VRD model—comprising VGG16, ResNet50V2, and DenseNet121—provides robust feature extraction and strong generalization capabilities for accurately classifying normal, benign, and malignant (cancerous) cases. To actively mitigate data imbalance and reduce model overfitting, real-time data augmentation alongside rigorous class weighting was implemented. The results show that, with 97.27% accuracy and a 97.24% F1-score, the WGM ensemble of these models performs exceptionally well. Furthermore, Gradient-weighted Class Activation Mapping (Grad-CAM) visualization was investigated on CT images to provide an exploratory qualitative visualization of the image regions associated with model predictions. While the proposed framework shows promise as an effective tool for automated lung cancer diagnosis, its validation is currently limited to the IQ-OTH/NCCD dataset. External dataset evaluation will be essential to fully establish robustness and clinical applicability.
Abstract from DOAJ. Public domain (CC0 1.0).
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Jozi, N., Al-Suhail, G., Pham, V. (2026). LCD-VRD: An Explainable Ensemble Deep Learning Framework for Lung Cancer Detection from CT Scans. BioMedInformatics. https://doi.org/10.3390/biomedinformatics6030036