Interdisciplinary Neurosurgery · Published 2026-08-01 · DOI 10.1016/j.inat.2026.102329
Yunhe Gao, Li Yan, Dayong Wang, Zhaoguo Gao, Jian Pei, Xiang Xu
ObjectiveTo construct a nomogram model based on the triglyceride-glucose index (TyG) and other factors to predict in-stent stenosis (ISS) after flow diverter (FD) treatment in patients with intracranial aneurysms. Methods A total of 224 patients with intracranial aneurysms admitted to the hospital from October 2015 to October 2024 were selected. All patients underwent FD treatment. Based on the occurrence of ISS 6 months after treatment, they were divided into an ISS group and a non-ISS group. Clinical data and preoperative TyG were compared between the two groups. A logistic regression model was used to analyze the influencing factors of ISS after FD treatment in patients with intracranial aneurysms, and a corresponding nomogram was constructed. Receiver operating characteristic (ROC) curves and calibration curves were used to evaluate the predictive efficacy and calibration of the nomogram. Results Logistic regression analysis showed that smoking (OR = 2.104, 95% CI: 1.268–3.490), aneurysm diameter (OR = 1.644, 95% CI: 1.062–2.543), FD malapposition (OR = 3.054, 95% CI: 1.419–6.574), and TyG (OR = 2.676, 95% CI: 1.394–5.139) were risk factors for ISS after FD treatment in patients with intracranial aneurysms (P < 0.05). The independent influencing factors of ISS after FD treatment were incorporated into the logistic regression equation: Logit(P) = −15.737+ 0.744 × 1+ 0.497 × 2+ 1.117 × 3+ 0.984 × 4. The ROC curve showed that the nomogram had a sensitivity of 92.68%, a specificity of 87.21%, and an area under the curve (AUC) of 0.925 (95% CI, 0.881–0.957) for predicting ISS after FD treatment. The Hosmer-Lemeshow test indicated no significant difference between the predicted probability and the actual probability of the nomogram for predicting ISS after FD treatment (χ2 = 7.823, P = 0.451). Conclusion Smoking, aneurysm diameter, FD malapposition, and TyG are risk factors for ISS after FD treatment in patients with intracranial aneurysms. The corresponding nomogram demonstrates good predictive efficacy upon validation.
Abstract from DOAJ. Public domain (CC0 1.0).
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Gao, Y., Yan, L., Wang, D., et al. (2026). Triglyceride-glucose index combined with other factors to construct a nomogram for predicting in-stent stenosis after flow diverter treatment in patients with intracranial aneurysms. Interdisciplinary Neurosurgery. https://doi.org/10.1016/j.inat.2026.102329