Applicability of LDL-cholesterol calculation formulas in hypertriglyceridemia: Insights from the Vojvodina

Journal of Medical Biochemistry · Published 2026-01-01 · DOI 10.5937/jomb0-61948

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Abstract

Background: Low-density lipoproteins cholesterol (LDL-C) is a key parameter for assessing the risk of atherosclerotic cardiovascular disease. Direct measurement of LDL-C is not always possible due to practical or financial reasons, making the use of calculation formulas essential. The aim of this study was to evaluate the applicability of four different formulas proposed by Friedewald, Sampson, Anandaraja, and Martin-Hopkins for calculating LDL-C compared to direct method in patients with serum triglyceride levels from 4.5 to 9.0 mmol/L in the population of Vojvodina. Methods: The retrospective study included 272 subjects whose lipid status parameters were measured between June 2022 and June 2023. LDL-C was determined by the direct method (d-LDL-C) on the Alinity c analyser (Abbott Laboratories, Illinois, USA). Calculated LDL-C values were obtained using the four selected formulas. Results: The average age of participants was 52 years, and the median concentration of triglycerides was 5.48 (4.94-6.58) mmol/L. A statistically significant positive correlation was found between d-LDL-C and all calculated LDL-C (P< 0.001). Linear regression analysis of the data showed the best agreement between d-LDL-C and the Sampson formula (slope=0.97; 95% C I=0.91 - 1.04). The smallest mean difference (MD) was observed between d-LDL-C and the Sampson formula (M D=-0.032). When comparing d-LDL-C and LDL-C values obtained by calculation, only the formula of Sampson et al. did not show a statistically significant difference (P= 0.240). Conclusion: In the studied population of patients with hypertriglyceridemia, the Sampson et al. formula showed the best performance compared with the others tested.

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Publication details

Year
2026

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