Journal of Orthopedic and Spine Trauma · Published 2025-08-23 · DOI 10.18502/jost.v11i3.19409
Background: Caudal regression syndrome (CRS), also known as sacral agenesis (SA), is a rare congenital disorder characterized by malformations of the caudal spine, lower limbs, urogenital, and anorectal systems. While the exact etiology remains unknown, a strong association with maternal diabetes mellitus (DM) has been observed. Case Report: This retrospective study includes two patients diagnosed with Renshaw type IV CRS who underwent spinopelvic fusion. Both patients presented with back pain, severe thoracolumbar (TL) kyphotic deformity, and difficulty in sitting. Postoperative outcomes demonstrated improved sitting ability, enhanced mobilization, increased self-esteem, and better overall quality of life. Conclusion: Orthopedic, neurological, and visceral anomalies are prevalent in patients with SA. Spinopelvic instability in type IV CRS significantly impairs sitting and mobilization. Surgical fusion can facilitate sitting and improve functional outcomes and cosmesis.
Abstract from DOAJ. Public domain (CC0 1.0).
Read the article at the publisher →