Lymphangioleiomyomatosis with superimposed organizing pneumonia diagnosed by transbronchial lung cryobiopsy: A case report

Respiratory Medicine Case Reports · Published 2026-01-01 · DOI 10.1016/j.rmcr.2026.102435

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Abstract

Lymphangioleiomyomatosis (LAM) is a cystic lung disease characterized by rounded, thin-walled cysts uniformly distributed within normal lung parenchyma on high-resolution chest computed tomography. We report a case of diffuse cystic lung disease with multiple alveolar opacities. Transbronchial lung biopsy showed organizing pneumonia, but LAM cells were not observed. She was diagnosed with cryptogenic organizing pneumonia (COP) and treated with corticosteroid therapy. LAM was definitively diagnosed by transbronchial lung cryobiopsy about two years after completing corticosteroid therapy for COP. We reported the first case of LAM with concomitant COP.

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Publication details

Year
2026

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