The glycolysis-H4K12la-PKM2 positive feedback loop drives M2 polarization of macrophages in colorectal cancer

Clinical Epigenetics · Published 2026-07-13 · DOI 10.1186/s13148-026-02200-2

Free full text

Authors (11)

Zhuo Zhang, Qiaoling Peng, Shaohu Wang, Quan Xun, Xingming Chen, Mingliang Zhou, Jianguan Luo, Lishun Yang, Chunming Tang, Yiqing Luo, Junlin Liu

Abstract

PubPorta does not have an abstract for this article yet.

Read the article at the publisher →

Publication details

Year

2026

Citation

Zhang, Z., Peng, Q., Wang, S., et al. (2026). The glycolysis-H4K12la-PKM2 positive feedback loop drives M2 polarization of macrophages in colorectal cancer. Clinical Epigenetics. https://doi.org/10.1186/s13148-026-02200-2

Related articles

• Histone lactylation: a novel epigenetic bridge linking cellular metabolism to benign and malignant gynecological diseases · Clinical Epigenetics · 2026 · Same journal
• TCA-controlled histone succinylation identifies IDH3B as a prognostic and therapeutic target in AML · Clinical Epigenetics · 2026 · Same journal
• Exploring a targeted epigenetic clock based on mortality-associated CpGs as a potential biomarker for frailty · Clinical Epigenetics · 2026 · Same journal
• Research progress and trends on epigenetics and endometriosis: a bibliometric analysis · Clinical Epigenetics · 2026 · Same journal
• Aging-driven transcriptional programs in diabetic kidney disease: multi-omics discovery of diagnostic biomarkers and drug-repurposing targets · Clinical Epigenetics · 2026 · Same journal
• Azacitidine and decitabine show distinct response patterns in pediatric Myelodysplastic Syndromes and Juvenile Myelomonocytic Leukemia before HSCT: a systematic review and quantitative analysis · Clinical Epigenetics · 2026 · Same journal
• Epstein–Barr Virus–host epigenetic interplay: mechanisms of regulation and therapeutic potential · Clinical Epigenetics · 2026 · Same journal
• Epigenetic editing approaches maturity: AI-driven precision design, delivery innovation, and the road to clinical translation · Clinical Epigenetics · 2026 · Same journal
• Lactate-driven metabolic–epigenetic reprogramming in breast cancer: immune evasion and therapeutic resistance · Clinical Epigenetics · 2026 · Same journal
• Accelerated biological aging mediates the associations of plasma lactate and the glucose-lactate index with MASLD: a prospective cohort study · Clinical Epigenetics · 2026 · Same journal