Recent advances in Epstein–Barr virus vaccines development from mechanistic exploration to clinical translation

npj Vaccines · Published 2026-05-20 · DOI 10.1038/s41541-026-01486-w

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Authors (8)

Liwei Hong, Juju Zhou, Junjuan Tan, Xiaoqian Zhu, Weihan Chen, Song Xie, Baotian Huang, Kai Chen

Abstract

Abstract Epstein–Barr virus (EBV) is a ubiquitous oncogenic virus linked to malignancies and autoimmune diseases. No licensed vaccines are currently available. Recent advances in EBV biology have enabled rational antigen selection and accelerated development of multivalent vaccines using platforms such as mRNA and nanoparticles. This review outlines key mechanisms, vaccine targets, and platform innovations, and discusses major challenges and future directions for EBV vaccine development.

Abstract from DOAJ. Public domain (CC0 1.0).

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Publication details

Year
2026

Citation

Hong, L., Zhou, J., Tan, J., et al. (2026). Recent advances in Epstein–Barr virus vaccines development from mechanistic exploration to clinical translation. npj Vaccines. https://doi.org/10.1038/s41541-026-01486-w

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