Autocrine Fibroblast Growth Factor Receptor 1 Signaling Activates Lactate Dehydrogenase A‐Aerobic Glycolysis for Advanced Human Prostate Tumor Growth

Prostate Cancer · Published 2025-01-01 · DOI 10.1155/proc/8862153

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Abstract

Conclusion: Our data indicate autocrine FGF/FGFR1 signaling regulates aerobic glycolysis in PCa DU145 cells via LDHA, suggesting the potential of targeting FGFs/FGFRs-LDHA for the management of advanced PCa. The regulation of aerobic glycolysis by other growth factors in PCa remains further investigation.

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Year
2025

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