American Heart Journal Plus · Published 2026-07-01 · DOI 10.1016/j.ahjo.2026.100829
Background: Cardiovascular diseases (CVDs) remain a leading cause of morbidity in Yemen. This study evaluates integrated lipid, renal, and hepatic function profiles in CVD patients to provide clinical insights into multi-organ metabolic associations in a resource-limited setting. Methods: This hospital-based, case-control study at Al-Gomhouri Hospital, Hajjah, Yemen, enrolled 320 participants (160 CVD patients and 160 age- and sex-matched controls). Assessments included lipid profiles, renal markers (uric acid, creatinine), and hepatic markers (albumin, total protein). Multivariate logistic regression identified factors associated with CVD status. Results: CVD patients exhibited severe atherogenic dyslipidemia, with significantly higher Total Cholesterol (269.7 ± 43.83 mg/dL) and Triglycerides (246.0 ± 58.97 mg/dL) than controls (P < 0.001). Markers of organ stress were pronounced in the CVD group, notably higher Serum Uric Acid (7.59 ± 0.95 vs. 3.9 ± 0.63 mg/dL). Khat chewing was more prevalent among CVD patients (84.4%) versus controls (41.2%; P < 0.001), with longer duration and higher frequency in the disease group. After adjusting for confounders, multivariate logistic regression identified Stage 2 hypertension (OR: 4.15) and elevated creatinine (OR: 3.40) as prominent independent factors associated with CVD status (P < 0.001). Conclusion: Significant alterations in cardiorenal and hepatic biomarkers characterize CVD patients in Hajjah. Stage 2 hypertension, hyperuricemia, and elevated creatinine are critical metabolic factors, highlighting the necessity of integrated multi-organ biochemical screening over isolated lipid assessments for improved risk stratification in high-risk populations.
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Alqadhi, Y. (2026). Assessment of lipid profile abnormalities and associated biochemical markers among cardiovascular disease patients in Hajjah Governorate, Yemen: A case-control study. American Heart Journal Plus. https://doi.org/10.1016/j.ahjo.2026.100829