Innovate or Be Left Behind: A Path to Prospective External Control Arms for Accelerated Oncology Drug Development

Journal of Clinical Oncology · Published 2026-08-05 · DOI 10.1200/jco-26-01081

Authors (6)

Stephen M. Hahn, Norman E. Sharpless, Christer Svedman, William B. Capra, Mark Lee, Mark A. Socinski

Abstract

PubPorta does not have an abstract for this article yet.

Read the article at the publisher →

Publication details

Year

2026

Citation

Hahn, S., Sharpless, N., Svedman, C., et al. (2026). Innovate or Be Left Behind: A Path to Prospective External Control Arms for Accelerated Oncology Drug Development. Journal of Clinical Oncology. https://doi.org/10.1200/jco-26-01081

Related articles

• Human and financial consequences of herding in oncology drug development: clinical trials of TIGIT inhibitors · BMJ Oncology · 2026 · Cites or is cited by this article
• Statistical and Methodological Considerations in the Evaluation of Ultra-Low-Dose Nivolumab · Journal of Clinical Oncology · 2026 · Same journal
• Virtual Sustained Tobacco Treatment for Patients With Cancer: A Randomized Controlled Trial (ECOG-ACRIN: EAQ171CD) Within the National Cancer Institute Community Oncology Research Program · Journal of Clinical Oncology · 2026 · Same journal
• AAML1831: A Phase III Trial Comparing Standard Induction Therapy With CPX-351 in De Novo Pediatric AML: A Report From the Children's Oncology Group · Journal of Clinical Oncology · 2026 · Same journal
• Clinical and Psychological Outcomes After Monoclonal Gammopathy Screening: A Population-Based Screening Study and Subsequent Randomized Trial of Follow-Up · Journal of Clinical Oncology · 2026 · Same journal
• Phase I/II Study of Sonrotoclax (BGB-11417) Monotherapy in Patients With Mantle Cell Lymphoma Previously Treated With Anti-CD20 Therapy and a Bruton Tyrosine Kinase Inhibitor · Journal of Clinical Oncology · 2026 · Same journal
• SKYSCRAPER-01: Tiragolumab in Combination With Atezolizumab in Previously Untreated PD-L1–High, Locally Advanced, Unresectable or Metastatic Non–Small Cell Lung Cancer · Journal of Clinical Oncology · 2026 · Same journal
• Moderate Hypofractionation for Regional Node Irradiation Is Safe and Effective · Journal of Clinical Oncology · 2026 · Same journal
• Beyond Statistical Significance: Methodological Fragility and Censoring Bias in the 5-Year Update of CheckMate 743 · Journal of Clinical Oncology · 2026 · Same journal
• Limiting Dexamethasone Exposure With Highly Emetogenic Chemotherapy Regimens: Is the Verdict In? · Journal of Clinical Oncology · 2026 · Same journal