The Aging Male · Available online 26 Jun 2026 · In press · DOI 10.1080/13685538.2026.2685423
Qingze Xiao, Wei Xiao
Background Based on data from the China Health and Retirement Longitudinal Study (CHARLS) and a Hunan cross-sectional study, the study investigated the link between metabolic heterogeneity of obesity (MHO) and lower urinary tract symptoms associated with benign prostatic hyperplasia (LUTS/BPH).Methods The cohort study included 2278 males, and the cross-sectional study included 851 males; all were divided into four BMI-metabolic categories: MHNW, MUNW, MHOO, and MUOO.Results This cross-sectional study found LUTS/BPH patients were younger, more urban-dwelling, with higher education and MHOO/MUOO prevalence. Both studies showed age, residence, education, obesity, and metabolic heterogeneity were linked with LUTS/BPH; CHARLS also linked arthritis and liver illness to LUTS/BPH.Conclusions Logistic regression showed unadjusted associations for MHOO (OR = 1.84, 95% CI: 1.22–2.78, p = 0.0038) and MUOO (OR = 1.59, 95% CI: 1.15–2.19, p = 0.0051), but only MHOO remained significant after adjusting for age and multiple factors, indicating that it was independently associated with LUTS/BPH regardless of confounders.
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Xiao, Q., Xiao, W. (2026). Associations of metabolic heterogeneity of obesity with lower urinary tract symptoms suggestive of benign prostatic hyperplasia (LUTS/BPH): longitudinal cohort and cross-sectional study. The Aging Male. https://doi.org/10.1080/13685538.2026.2685423