Journal of Ophthalmic & Vision Research · Published 2025-09-09 · DOI 10.18502/jovr.v20.15749
Purpose: To present our experience of cases who presented with donor implanted guttata (DIG) in patients who underwent uncomplicated corneal transplants. Method: Case series. Results: Four patients who underwent corneal transplantation were diagnosed with donor-implanted guttata following their corneal graft, this was confirmed by confocal microscopy. Three cases received Descemet’s membrane endothelial keratoplasty (DMEK) and one case received a penetrating keratoplasty (PK). Two of the DMEK cases received corneas from the same donor and experienced delayed recovery of corneal transparency despite having fully attached grafts. Another case of DIG in a DMEK was found in a patient with graft failure just three years after their DMEK transplantation. The final case we present received PK’s for Fuchs dystrophy in both eyes 35 years ago. The left eye was confirmed as having guttata on a routine follow-up despite a clear cornea. The right eye which had also received a PK had no signs of guttata. Conclusion: Fuchs endothelial dystrophy is a common condition within the general population and is likely to appear in donor corneas. We discuss four cases of donor-implanted guttata and highlight the need for this condition to be better screened for prior to transplantation and for it to be considered in the early post-op period if there is any evidence of corneal edema despite graft attachment.
Abstract from DOAJ. Public domain (CC0 1.0).
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