Clinical Immunology Communications · Published 2026-01-24 · DOI 10.1016/j.clicom.2026.01.005
Background: Cytopenias may be an initial presentation among inborn errors of immunity (IEI), but their frequency and clinical associations have not been characterized. Methods: We evaluated cytopenias, mortality, infections, malignancies, and comorbidities among 3,511 patients in the United States Immunodeficiency Network Registry. Results: Of the 3,511 patients analyzed, 2,087 (59.4 %) were classified as having antibody deficiencies. Common variable immunodeficiency was most common (40.3 %). Approximately 27.0 % of patients were reported to have at least one cytopenia with anemia in 15.8 %, thrombocytopenia in 11.1 %, neutropenia in 7.2 %, and lymphopenia in 6.7 %. IEI patients carried a 13.5-fold higher rate of cytopenias as compared to general population. Among cytopenias, 239/947 (25.2 %) were immune-mediated. Cytopenias were associated with mortality, infections, malignancies, and lung disease. Conclusion: This study presents the largest cohort of IEI patients assessed for cytopenias in the US to date, underscoring the need for prompt recognition and evaluation of correlated clinical outcomes.
Abstract from DOAJ. Public domain (CC0 1.0).
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