Isolation of Infectious Highly Pathogenic Avian Influenza A(H5N1) Virus from Fetal Bovine Serum, United States, 2025

Emerging Infectious Diseases · Published 2026-07-09 · DOI 10.3201/eid3208.260077

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Authors (11)

Ana R. Rebelo, Erica Buttler, Elizabeth Aguilera Nunez, Brittany Cronk, Jennifer Powers, Melissa Laverack, Chen Feng, Mohammed Nooruzzaman, Mia K. Torchetti, Leonardo C. Caserta, Diego G. Diel

Abstract

In February 2025, we detected highly pathogenic avian influenza virus A(H5N1) clade 2.3.4.4b virus in a fetal bovine serum lot during routine adventitious agent testing. Sequencing confirmed H5N1 genotype B3.13 virus. We found low viral loads in additional samples from the same lot. Heating at 56°C for 30 minutes completely inactivated the virus.

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Publication details

Year
2026

Citation

Rebelo, A., Buttler, E., Nunez, E., et al. (2026). Isolation of Infectious Highly Pathogenic Avian Influenza A(H5N1) Virus from Fetal Bovine Serum, United States, 2025. Emerging Infectious Diseases. https://doi.org/10.3201/eid3208.260077

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