Effect of adalimumab on anxiety-depression-like behaviors and learning in rats receiving cisplatin

Open Medicine · Published 2026-01-01 · DOI 10.1515/med-2026-1406

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Abstract

To investigate the neuroprotective effects of adalimumab against cisplatin-induced cognitive impairment (CICI) and to evaluate its potential to ameliorate anxiety- and depression-like behaviors as well as learning and memory deficits through modulation of Tumor necrosis factor-α (TNF-α)–mediated neuroinflammation, cholinergic homeostasis, and apoptosis.

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Year
2026

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