Ozone-activated platelet-rich plasma combined with occlusal splint therapy in the treatment of temporomandibular joint osteoarthritis

Revista Portuguesa de Estomatologia, Medicina Dentária e Cirurgia Maxilofacial · Published 2026-06-30 · DOI 10.24873/j.rpemd.2026.06.1572

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Authors (2)

Reynier Ramírez, Yoan Arango

Abstract

Objectives: To evaluate the efficacy of intra-articular infiltration of ozone-activated platelet-rich plasma combined with occlusal splint therapy in the treatment of patients with temporomandibular joint osteoarthritis. Methods: A quasi-experimental study was conducted in 21 patients, who were allocated into three groups using matching methods. Each group received a different therapeutic modality: intra-articular infiltration of ozone-activated platelet-rich plasma, a stabilization splint, and intra-articular infiltration of ozone-activated platelet-rich plasma combined with a stabilization splint. The variables analyzed were age, mouth opening, and pain. Patients were evaluated at baseline, 4 weeks, and 3 months. Results: No significant differences were observed in mean age among the treatment cohorts. All patients improved mouth opening; however, those receiving ozone-activated platelet-rich plasma combined with occlusal splint achieved significantly superior outcomes compared with stabilization splint alone (p=0.0005). The combined therapy also showed higher mean values than the platelet‑rich plasma activated with ozone, although without statistical significance (p=0.0716). All patients showed improvement in pain, with combined therapy yielding superior results (p=0.0155). Conclusions: Intra-articular infiltration of ozone-activated platelet-rich plasma combined with occlusal splint therapy is associated with significantly superior outcomes in the recovery of mouth opening and pain relief compared with the independent application of ozone-activated platelet-rich or occlusal splint therapy alone.

Abstract from DOAJ. Public domain (CC0 1.0).

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Publication details

Year
2026

Citation

Ramírez, R., Arango, Y. (2026). Ozone-activated platelet-rich plasma combined with occlusal splint therapy in the treatment of temporomandibular joint osteoarthritis. Revista Portuguesa de Estomatologia, Medicina Dentária e Cirurgia Maxilofacial. https://doi.org/10.24873/j.rpemd.2026.06.1572

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