Photodiagnosis and Photodynamic Therapy · Published 2026-06-01 · DOI 10.1016/j.pdpdt.2026.105557
Dongli Kong, Chun Gao, Li Li, Ruqi Chen, Yi Ding, Min lu, Cui Xing, Wei Li, Nan Yu
Objective: To compare the efficacy of laser ablation combined with photodynamic therapy (LA-PDT) versus PDT alone in the treatment of cervical intraepithelial neoplasia grade 2/3 (CIN2/3). Methods: Patients diagnosed with CIN2/3 were enrolled and allocated to either the LA-PDT or the PDT group based on patients' choice. Pathological regression and human papillomavirus (HPV) clearance were compared at 12-month follow-up between the two groups. Results: A total of 77 patients in the LA-PDT group and 68 patients in the PDT group completed follow-up. Baseline characteristics showed no significant differences between the two groups. At the 12-month follow-up, both the pathological complete remission rate and HPV clearance rate were significantly higher in the LA-PDT group compared to the PDT group (98.7%vs. 86.4%, P < 0.05; 92.3% vs. 86.4%, P < 0.05). Univariate and multivariate analyses indicated that the pre-treatment pathology of CIN3 was an independent risk factor for both lesion persistence and HPV persistence. Among the 111 patients with CIN2, the pathological complete remission rate was 98.2% and the HPV clearance rate was 95.5%. Among the 33 patients with CIN3, both the pathological complete remission rate and HPV clearance rate were significantly higher in the LA-PDT group than in the PDT group (94.1%vs. 56.3%, P < 0.05; 76.5% vs. 37.5%, P < 0.05). Conclusion: LA-PDT for CIN2/3 demonstrates high efficacy and potentially saves time and economic costs. The combined therapy shows significant advantages over PDT alone, particularly for patients with CIN3.
Abstract from DOAJ. Public domain (CC0 1.0).
Read the article at the publisher →
Kong, D., Gao, C., Li, L., et al. (2026). The efficacy of laser ablation combined with photodynamic therapy vs PDT for CIN2/3 in reproductive women: a prospective case-control study. Photodiagnosis and Photodynamic Therapy. https://doi.org/10.1016/j.pdpdt.2026.105557