Case Reports in Psychiatry · Published 2025-01-01 · DOI 10.1155/crps/9578923
Managing aggressive behaviors in patients with substance use disorders (SUDs), particularly when accompanied by comorbid psychiatric disorders, presents considerable challenges. Clozapine is an atypical antipsychotic known for its effectiveness in treatment-resistant schizophrenia with evidence in support of its ability to reduce violent and aggressive behaviors. This case report describes two patients who were treated with clozapine and showed reduction in violent behaviors, as well as improvement in addiction issues during their stay in a secure rehabilitation center. This observation suggests that clozapine may offer considerable benefits in managing aggression in SUD patients with co-occurring psychiatric illness and highlights the need for further research to assess its broader applicability in complex cases beyond treatment resistant schizophrenia.
Abstract from DOAJ. Public domain (CC0 1.0).
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