Journal of Intensive Care · Published 2026-07-01 · DOI 10.1186/s40560-026-00898-z
Luis Chiscano-Camon, Juan Carlos Ruiz-Rodríguez, Adolf Ruiz-Sanmartin, Pablo Nicolas-Morales, Manuel Hernandez-Gonzalez, Ricard Ferrer
Abstract Sepsis and septic shock remain a global health challenge with high mortality and long-term morbidity. Contemporary evidence highlights immune dysregulation, endothelial dysfunction, and glycocalyx degradation as key pathophysiological drivers. Clinical management has evolved from uniform approaches to precision-guided strategies that integrate subphenotyping, biomarkers and novel therapies. This review synthesizes data from guidelines, translational research, and clinical trials to provide a comprehensive perspective on current management and future directions in sepsis care.
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Chiscano-Camon, L., Ruiz-Rodríguez, J., Ruiz-Sanmartin, A., et al. (2026). Update on sepsis treatment. Journal of Intensive Care. https://doi.org/10.1186/s40560-026-00898-z